3-Bromopentane → 2-Ethyl-1-(1-ethylpropyl)-4-(trifluoromethyl)-1H-indole-5-carbonitrile

HRID 2101968Notes

Reaction equation

HRID 2101968 reaction equation
[CH2:1]([C:3]1[NH:4][C:5]2[C:10]([CH:11]=1)=[C:9]([C:12]([F:15])([F:14])[F:13])[C:8]([C:16]#[N:17])=[CH:7][CH:6]=2)[CH3:2].Br[CH:19]([CH2:22][CH3:23])[CH2:20][CH3:21]>>[CH2:1]([C:3]1[N:4]([CH:19]([CH2:22][CH3:23])[CH2:20][CH3:21])[C:5]2[C:10]([CH:11]=1)=[C:9]([C:12]([F:15])([F:13])[F:14])[C:8]([C:16]#[N:17])=[CH:7][CH:6]=2)[CH3:2]

Participants

3

Reactant 2

HCID 157383-BromopentaneHCID 674038192-ethyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile

Product 1

HCID 674051362-Ethyl-1-(1-ethylpropyl)-4-(trifluoromethyl)-1H-indole-5-carbonitrile

Procedure

Synthesized as described in Example 145B from 2-ethyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile and 3-bromopentane: MS (ESI): m/z 309 (M+1).

Workup

  1. customSynthesized

Sources & evidence

ORD record
ord-fb7ccdc7305949c49765fd5861332773
Source dataset
uspto-grants-2009_08
Patent number
US07572820B2

Reaction notes

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