5-[3,5-Bis(trifluoromethyl)phenyl]-3-(chloromethyl)-1,2,4-oxadiazole → HCID 86620672, compound

HRID 2101971Notes

Reaction equation

HRID 2101971 reaction equation
[CH2:1]([C:3]1[NH:4][C:5]2[C:10]([CH:11]=1)=[C:9]([C:12]([F:15])([F:14])[F:13])[C:8]([C:16]#[N:17])=[CH:7][CH:6]=2)[CH3:2].[F:18][C:19]([F:38])([F:37])[C:20]1[CH:21]=[C:22]([C:30]2[O:34][N:33]=[C:32]([CH2:35]Cl)[N:31]=2)[CH:23]=[C:24]([C:26]([F:29])([F:28])[F:27])[CH:25]=1>>[F:38][C:19]([F:18])([F:37])[C:20]1[CH:21]=[C:22]([C:30]2[O:34][N:33]=[C:32]([CH2:35][N:4]3[C:5]4[C:10](=[C:9]([C:12]([F:15])([F:13])[F:14])[C:8]([C:16]#[N:17])=[CH:7][CH:6]=4)[CH:11]=[C:3]3[CH2:1][CH3:2])[N:31]=2)[CH:23]=[C:24]([C:26]([F:28])([F:27])[F:29])[CH:25]=1

Participants

3

Reactant 2

HCID 27809575-[3,5-Bis(trifluoromethyl)phenyl]-3-(chloromethyl)-1,2,4-oxadiazoleHCID 674038192-ethyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile

Product 1

HCID 86620672HCID 86620672, compound

Procedure

Synthesized as described in Example 145B from 2-ethyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile and 5-[3,5-bis(trifluoromethyl)phenyl]-3-(chloromethyl)-1,2,4-oxadiazole: MS (ESI): m/z 533 (M+1).

Workup

  1. customSynthesized

Sources & evidence

ORD record
ord-e7d67587dc564f16be6bdaea22abef45
Source dataset
uspto-grants-2009_08
Patent number
US07572820B2

Reaction notes

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