HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromomethylcyclopropane → 1-(Cyclopropylmethyl)-2-propyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromomethylcyclopropane | HCID 81503 | — |
| Reactant | 2-propyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile | HCID 67405155 | — |
| Product | 1-(Cyclopropylmethyl)-2-propyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile | HCID 67406386 | — |
Reaction Steps
Synthesized as described in Example 4 using 2-propyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile and (bromomethyl)cyclopropane: 1H NMR (400 MHz, CDCl3) δ 7.49 (s, 2H), 6.57 (s, 1H), 4.05 (d, J=6.4 Hz, 2H), 2.76 (t, J=7.6 Hz, 2H), 1.83 (m, 2H), 1.16 (m, 1H), 1.08 (t, J=7.4 Hz, 3H), 0.60 (m, 2H), 0.35 (m, 2H); MS (ES) m/z 307 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07572820B2 |
| Source dataset | uspto-grants-2009_08 |
| ORD ID | ord-b1e1f073a03c4a68b7e382cb8f7c1c8a |
| Source note | uspto-grants-2009_08 |