tert-Butyl bromoacetate → 1,1-Dimethylethyl (4-chloro-5-cyano-2-ethyl-1H-benzimidazol-1-yl)acetate

HRID 2102006Notes

Reaction equation

HRID 2102006 reaction equation
[Cl:1][C:2]1[C:10]2[N:9]=[C:8]([CH2:11][CH3:12])[NH:7][C:6]=2[CH:5]=[CH:4][C:3]=1[C:13]#[N:14].Br[CH2:16][C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18]>>[Cl:1][C:2]1[C:10]2[N:9]=[C:8]([CH2:11][CH3:12])[N:7]([CH2:16][C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[C:6]=2[CH:5]=[CH:4][C:3]=1[C:13]#[N:14]

Participants

3

Reactant 2

HCID 79177tert-Butyl bromoacetateHCID 674049024-chloro-2-ethyl-1H-benzimidazole-5-carbonitrile

Product 1

HCID 690359901,1-Dimethylethyl (4-chloro-5-cyano-2-ethyl-1H-benzimidazol-1-yl)acetate

Procedure

Synthesized as described in Example 197B from 4-chloro-2-ethyl-1H-benzimidazole-5-carbonitrile and 1,1-dimethylethyl bromoacetate: MS (ESI) m/z 320 (M+1).

Workup

  1. customSynthesized

Sources & evidence

ORD record
ord-455ce62668674fadb9e58de0b6905dfe
Source dataset
uspto-grants-2009_08
Patent number
US07572820B2

Reaction notes

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