6-(Trifluoromethyl)nicotinohydrazide → 4-Chloro-2-ethyl-1-({5-[6-(trifluoromethyl)-3-pyridinyl]-1,3,4-oxadiazol-2-yl}methyl)-1H-benzimidazole-5-carbonitrile

HRID 2102009Notes

Reaction equation

HRID 2102009 reaction equation
[Cl:1][C:2]1[C:10]2[N:9]=[C:8]([CH2:11][CH3:12])[N:7]([CH2:13][C:14]([OH:16])=O)[C:6]=2[CH:5]=[CH:4][C:3]=1[C:17]#[N:18].[F:19][C:20]([F:32])([F:31])[C:21]1[N:26]=[CH:25][C:24]([C:27]([NH:29][NH2:30])=O)=[CH:23][CH:22]=1>>[Cl:1][C:2]1[C:10]2[N:9]=[C:8]([CH2:11][CH3:12])[N:7]([CH2:13][C:14]3[O:16][C:27]([C:24]4[CH:25]=[N:26][C:21]([C:20]([F:32])([F:19])[F:31])=[CH:22][CH:23]=4)=[N:29][N:30]=3)[C:6]=2[CH:5]=[CH:4][C:3]=1[C:17]#[N:18]

Participants

3

Reactant 2

HCID 27775536-(Trifluoromethyl)nicotinohydrazideHCID 67404468(4-Chloro-5-cyano-2-ethyl-1H-benzimidazol-1-yl)acetic acid

Product 1

HCID 674068054-Chloro-2-ethyl-1-({5-[6-(trifluoromethyl)-3-pyridinyl]-1,3,4-oxadiazol-2-yl}methyl)-1H-benzimidazole-5-carbonitrile

Procedure

Synthesized as described in Example 200C from (4-chloro-5-cyano-2-ethyl-1H-benzimidazol-1-yl)acetic acid and 6-(trifluoromethyl)-3-pyridinecarbohydrazide: MS (APCl) m/z 433 (M+1).

Workup

  1. customSynthesized

Sources & evidence

ORD record
ord-2c9c1414e9b748a78e2f301941c369f7
Source dataset
uspto-grants-2009_08
Patent number
US07572820B2

Reaction notes

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