4-(Chloromethyl)-1,3-thiazole hydrochloride → 4-Chloro-1-(1,3-thiazol-4-ylmethyl)-2-(trifluoromethyl)-1H-benzimidazole-5-carbonitrile

HRID 2102013Notes

Reaction equation

HRID 2102013 reaction equation
[Cl:1][C:2]1[C:10]2[N:9]=[C:8]([C:11]([F:14])([F:13])[F:12])[NH:7][C:6]=2[CH:5]=[CH:4][C:3]=1[C:15]#[N:16].Cl.Cl[CH2:19][C:20]1[N:21]=[CH:22][S:23][CH:24]=1>>[Cl:1][C:2]1[C:10]2[N:9]=[C:8]([C:11]([F:12])([F:13])[F:14])[N:7]([CH2:19][C:20]3[N:21]=[CH:22][S:23][CH:24]=3)[C:6]=2[CH:5]=[CH:4][C:3]=1[C:15]#[N:16]

Participants

3

Reactant 2

HCID 27632894-(Chloromethyl)-1,3-thiazole hydrochlorideHCID 674045324-chloro-2-(trifluoromethyl)-1H-benzimidazole-5-carbonitrile

Product 1

HCID 674054464-Chloro-1-(1,3-thiazol-4-ylmethyl)-2-(trifluoromethyl)-1H-benzimidazole-5-carbonitrile

Procedure

Synthesized as described in Example 197B from 4-chloro-2-(trifluoromethyl)-1H-benzimidazole-5-carbonitrile and 4-(chloromethyl)-1,3-thiazole hydrochloride: MS (ESI) m/z 343 (M+1).

Workup

  1. customSynthesized

Sources & evidence

ORD record
ord-25af46e7466f4b55958c3d406e29f8b1
Source dataset
uspto-grants-2009_08
Patent number
US07572820B2

Reaction notes

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