HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2102025Generated: November 1, 2026
Water → N-(4-Bromo-3-chloro-2-methylphenyl)acetamide
https://huagongshe.com/reaction/2102025
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Bromine | HCID 24408 | — |
| Reactant | N-(3-chloro-2-methylphenyl)acetamide | HCID 81969 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | N-(4-Bromo-3-chloro-2-methylphenyl)acetamide | HCID 86376 | 99.5% |
Reaction Steps
A suspension of N-(3-chloro-2-methylphenyl)acetamide (11.12 g, 60.63 mmol) in acetic acid (80 mL) was cooled to ca. 10° C. and then treated with bromine (9.28 mL, 181.11 mmol). The resulting mixture was stirred at rt for 2 h. The cooled solution was then poured into water (100 mL). The resulting solid was collected via filtration and rinsed with water. Thorough drying afforded 15.83 g of a pale yellow solid: MS (APCl) m/z 264 (M+2 isotope).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07572820B2 |
|---|
| Source dataset | uspto-grants-2009_08 |
|---|
| ORD ID | ord-8806f6d77e5f4a9fa1d02e926c4df7e0 |
|---|
| Source note | uspto-grants-2009_08 |
|---|
