HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(2-Bromoethoxy)-2,4-difluorobenzene → 4-Chloro-1-{2-[(2,4-difluorophenyl)oxy]ethyl}-2-propyl-1H-indole-5-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(2-Bromoethoxy)-2,4-difluorobenzene | HCID 23294261 | — |
| Reactant | 4-chloro-2-propyl-1H-indole-5-carbonitrile | HCID 67404338 | — |
| Product | 4-Chloro-1-{2-[(2,4-difluorophenyl)oxy]ethyl}-2-propyl-1H-indole-5-carbonitrile | HCID 57800224 | — |
Reaction Steps
Synthesized as described in Example 4 from 4-chloro-2-propyl-1H-indole-5-carbonitrile and 1-[(2-bromoethyl)oxy]-2,4-difluorobenzene: 1H NMR (400 MHz, DMSO-d6) δ 7.89 (s, 1H), 7.79 (d, J=8.7 Hz, 1H), 7.51 (d, J=8.7 Hz, 1H), 7.25-7.14 (m, 1H), 7.08-6.99 (m, 1H), 6.96-6.85 (m, 1H), 4.67 (t, J=4.9 Hz, 2H), 4.28 (t, J=4.9 Hz, 2H), 2.89 (t, J=7.3 Hz, 2H), 1.73-1.57 (m, 2H), 0.93 (t, J=7.3 Hz, 3H); MS (ES) m/z 375 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07572820B2 |
| Source dataset | uspto-grants-2009_08 |
| ORD ID | ord-175e240e5b604d52b8b72bbd4b118fcb |
| Source note | uspto-grants-2009_08 |