HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(2-Bromoethoxy)-2,4-difluorobenzene → 4-Chloro-1-{2-[(2,4-difluorophenyl)oxy]ethyl}-2-methyl-1H-indole-5-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(2-Bromoethoxy)-2,4-difluorobenzene | HCID 23294261 | — |
| Reactant | 4-chloro-2-methyl-1H-indole-5-carbonitrile | HCID 67404878 | — |
| Product | 4-Chloro-1-{2-[(2,4-difluorophenyl)oxy]ethyl}-2-methyl-1H-indole-5-carbonitrile | HCID 57800428 | — |
Reaction Steps
Synthesized as described in Example 4 from 4-chloro-2-methyl-1H-indole-5-carbonitrile and 1-[(2-bromoethyl)oxy]-2,4-difluorobenzene: 1H NMR (400 MHz, DMSO-d6) δ 7.88 (s, 1H), 7.76 (d, J=8.7 Hz, 1H), 7.50 (d, J=8.7 Hz, 1H), 7.26-7.15 (m, 1H), 7.10-7.00 (m, 1H), 6.92-6.88 (m, 1H), 4.67 (t, J=5.0 Hz, 2H), 4.30 (t, J=5.0 Hz, 2H), 3.30 (s, 3H); MS (ES) m/z 347 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07572820B2 |
| Source dataset | uspto-grants-2009_08 |
| ORD ID | ord-0ee4c9637f4244bbb21d6e550cf97b2f |
| Source note | uspto-grants-2009_08 |