HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-[3,5-Bis(trifluoromethyl)phenyl]-3-(chloromethyl)-1,2,4-oxadiazole → 1-({5-[3,5-bis(Trifluoromethyl)phenyl]-1,2,4-oxadiazol-3-yl}methyl)-4-chloro-2-(trifluoromethyl)-1H-indole-5-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-[3,5-Bis(trifluoromethyl)phenyl]-3-(chloromethyl)-1,2,4-oxadiazole | HCID 2780957 | — |
| Reactant | 4-chloro-2-(trifluoromethyl)-1H-indole-5-carbonitrile | HCID 67405660 | — |
| Product | 1-({5-[3,5-bis(Trifluoromethyl)phenyl]-1,2,4-oxadiazol-3-yl}methyl)-4-chloro-2-(trifluoromethyl)-1H-indole-5-carbonitrile | HCID 57800107 | — |
Reaction Steps
Synthesized as described in Example 4 from 4-chloro-2-(trifluoromethyl)-1H-indole-5-carbonitrile (Example 228B) and 5-[3,5-bis(trifluoromethyl)phenyl]-3-(chloromethyl)-1,2,4-oxadiazole: 1H NMR (400 MHz, DMSO-d6) δ 8.54 (s, 2H), 8.51 (s, 1H), 8.03-7.95 (m, 1H), 7.94-7.86 (m, 1H), 7.52 (s, 1H), 5.99 (s, 2H); MS (ES) m/z 539 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07572820B2 |
| Source dataset | uspto-grants-2009_08 |
| ORD ID | ord-4786d8bd46fe40cab407cba13ce1f7be |
| Source note | uspto-grants-2009_08 |