HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(Chloromethyl)-5-(3,5-difluorophenyl)-1,2,4-oxadiazole → 1-{[5-(3,5-Difluorophenyl)-1,2,4-oxadiazol-3-yl]methyl}-2-propyl-1H-indole-4,5-dicarbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(Chloromethyl)-5-(3,5-difluorophenyl)-1,2,4-oxadiazole | HCID 43120209 | — |
| Reactant | 2-propyl-1H-indole-4,5-dicarbonitrile | HCID 57800367 | — |
| Product | 1-{[5-(3,5-Difluorophenyl)-1,2,4-oxadiazol-3-yl]methyl}-2-propyl-1H-indole-4,5-dicarbonitrile | HCID 57800089 | — |
Reaction Steps
Synthesized as described in Example 4 from 2-propyl-1H-indole-4,5-dicarbonitrile and 3-(chloromethyl)-5-(3,5-difluorophenyl)-1,2,4-oxadiazole: 1H NMR (400 MHz, DMSO-d6) δ 8.15 (s, 1H), 7.85 (d, J=8.5 Hz, 1H), 7.75-7.62 (m, 4H), 5.94 (s, 2H), 3.06 (t, 2H), 1.77-1.65 (m, 2H), 0.95 (t, J=7.3 Hz, 3H): MS (ES) m/z 404 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07572820B2 |
| Source dataset | uspto-grants-2009_08 |
| ORD ID | ord-1dbcf773e8b14bda8511b1fb6de93093 |
| Source note | uspto-grants-2009_08 |