Methyl 2-bromopropionate → Methyl 2-(5-cyano-4-(trifluoromethyl)-1H-indol-1-yl)propanoate

HRID 2102073Notes

Reaction equation

HRID 2102073 reaction equation
[F:1][C:2]([F:15])([F:14])[C:3]1[C:11]([C:12]#[N:13])=[CH:10][CH:9]=[C:8]2[C:4]=1[CH:5]=[CH:6][NH:7]2.Br[CH:17]([CH3:22])[C:18]([O:20][CH3:21])=[O:19]>>[C:12]([C:11]1[C:3]([C:2]([F:14])([F:1])[F:15])=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH:17]([CH3:22])[C:18]([O:20][CH3:21])=[O:19])[CH:6]=[CH:5]2)#[N:13]

Participants

3

Reactant 2

HCID 95576Methyl 2-bromopropionateHCID 674054494-(trifluoromethyl)-1H-indole-5-carbonitrile

Product 1

HCID 57800469Methyl 2-(5-cyano-4-(trifluoromethyl)-1H-indol-1-yl)propanoate

Procedure

Synthesized as described in Example 4 from 4-(trifluoromethyl)-1H-indole-5-carbonitrile and methyl 2-bromopropanoate: MS (APCl) m/z 297 (M+1).

Workup

  1. customSynthesized

Sources & evidence

ORD record
ord-b6a28161896f47fda4a4ae6c65cdc9ce
Source dataset
uspto-grants-2009_08
Patent number
US07572820B2

Reaction notes

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