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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2102078Generated: October 26, 2026

5-(Chloromethyl)-3-phenylisoxazole → 1-[(3-Phenyl-5-isoxazolyl)methyl]-2-propyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile

https://huagongshe.com/reaction/2102078

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-(Chloromethyl)-3-phenylisoxazoleHCID 2764057—
Reactant2-propyl-4-(trifluoromethyl)-1H-indole-5-carbonitrileHCID 67405155—
Product1-[(3-Phenyl-5-isoxazolyl)methyl]-2-propyl-4-(trifluoromethyl)-1H-indole-5-carbonitrileHCID 67406614—

Reaction Steps

Synthesized in a manner similar to Example 23 using 2-propyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile and 5-(chloromethyl)-3-phenylisoxazole: MS (ES) m/z 410 (M+1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07572820B2
Source datasetuspto-grants-2009_08
ORD IDord-60ad7fa589cf4f48808377299be95fc4
Source noteuspto-grants-2009_08