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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2102081Generated: October 25, 2026

5-(Chloromethyl)-3-phenylisoxazole → 2-Methyl-1-[(3-phenyl-5-isoxazolyl)methyl]-4-(trifluoromethyl)-1H-indole-5-carbonitrile

https://huagongshe.com/reaction/2102081

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-(Chloromethyl)-3-phenylisoxazoleHCID 2764057—
Reactant2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrileHCID 53309346—
Product2-Methyl-1-[(3-phenyl-5-isoxazolyl)methyl]-4-(trifluoromethyl)-1H-indole-5-carbonitrileHCID 67405441—

Reaction Steps

Synthesized in a manner similar to Example 23 using 2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile and 5-(chloromethyl)-3-phenylisoxazole:

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07572820B2
Source datasetuspto-grants-2009_08
ORD IDord-61bce23138184c378eb5026c45d6ad6d
Source noteuspto-grants-2009_08