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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2102135Generated: October 26, 2026

(3,5-Difluorophenyl)boronic acid → 1-{[2-(3,5-Difluorophenyl)-1,3-thiazol-4-yl]methyl}-2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile

https://huagongshe.com/reaction/2102135

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(3,5-Difluorophenyl)boronic acidHCID 2734338—
Reactant1-[(2-Bromo-1,3-thiazol-4-yl)methyl]-2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrileHCID 67404358—
Product1-{[2-(3,5-Difluorophenyl)-1,3-thiazol-4-yl]methyl}-2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrileHCID 67406112—

Reaction Steps

Synthesized as described in Example 310D using 1-[(2-bromo-1,3-thiazol-4-yl)methyl]-2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile (Example 311B) and [3,5-difluorophenyl]boronic acid: MS (ES) m/z 434 (M+1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07572820B2
Source datasetuspto-grants-2009_08
ORD IDord-b2c7d7ee4f544e7bab582e5733556114
Source noteuspto-grants-2009_08