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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 2102143생성일: 2026년 10월 25일

3-(Trifluoromethyl)phenylboronic acid → 2-Methyl-4-(trifluoromethyl)-1-{[3'-(trifluoromethyl)-3-biphenylyl]methyl}-1H-indole-5-carbonitrile

https://huagongshe.com/reaction/2102143

반응식

참여 물질

역할이름HCID투입량
반응물3-(Trifluoromethyl)phenylboronic acidHCID 2734388—
반응물1-[(3-Bromophenyl)methyl]-2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrileHCID 67405035—
생성물2-Methyl-4-(trifluoromethyl)-1-{[3'-(trifluoromethyl)-3-biphenylyl]methyl}-1H-indole-5-carbonitrileHCID 86620702—

반응 단계

Synthesized as described in Example 310D using 1-[(3-bromophenyl)methyl]-2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile (Example 318A) and [3-(trifluoromethyl)phenyl]boronic acid: 1H NMR (400 MHz, CDCl3) δ 7.73 (s, 1H), 7.65-7.35 (m, 8H), 6.81 (d, J=7.6 Hz, 1H), 6.68 (s, 1H), 5.44 (s, 2H), 2.48 (s, 3H): MS (ES) m/z 459 (M+1).

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US07572820B2
출처 데이터셋uspto-grants-2009_08
ORD IDord-d9728d77bd6644d0b5bbf6ba57c4de09
출처 메모uspto-grants-2009_08