3,5-Bis-trifluoromethylphenylboronic acid → HCID 57800263, compound

HRID 2102146Notes

Reaction equation

HRID 2102146 reaction equation
Br[C:2]1[S:3][C:4]([C:7]([O:9][CH3:10])=[O:8])=[CH:5][N:6]=1.[F:11][C:12]([F:27])([F:26])[C:13]1[CH:14]=[C:15](B(O)O)[CH:16]=[C:17]([C:19]([F:22])([F:21])[F:20])[CH:18]=1>>[F:11][C:12]([F:26])([F:27])[C:13]1[CH:14]=[C:15]([C:2]2[S:3][C:4]([C:7]([O:9][CH3:10])=[O:8])=[CH:5][N:6]=2)[CH:16]=[C:17]([C:19]([F:20])([F:21])[F:22])[CH:18]=1

Participants

3

Reactant 2

HCID 1562653,5-Bis-trifluoromethylphenylboronic acidHCID 2773502Methyl 2-bromothiazole-5-carboxylate

Product 1

HCID 57800263HCID 57800263, compound

Procedure

Synthesized as described in Example 310D using methyl 2-bromo-1,3-thiazole-5-carboxylate and [3,5-bis(trifluoromethyl)phenyl]boronic acid: 1H NMR (400 MHz, CDCl3) δ 8.51 (s, 1H), 8.44 (s, 2H), 7.99 (s, 1H), 3.98 (s, 3H).

Workup

  1. customSynthesized

Sources & evidence

ORD record
ord-8be38f82b83b4513ae9673325ad5d60f
Source dataset
uspto-grants-2009_08
Patent number
US07572820B2

Reaction notes

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