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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2102161Generated: October 29, 2026

6-Fluoropyridin-3-ol → 1-{(1R)-2-[(6-Fluoro-3-pyridinyl)oxy]-1-methylethyl}-2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile

https://huagongshe.com/reaction/2102161

Reaction equation

Participants

RoleNameHCIDCharge
Reactant6-Fluoropyridin-3-olHCID 2763108—
Reactant1-[(1R)-2-Hydroxy-1-methylethyl]-2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrileHCID 67404820—
Product1-{(1R)-2-[(6-Fluoro-3-pyridinyl)oxy]-1-methylethyl}-2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrileHCID 67405147—

Reaction Steps

Synthesized as described in Example 139C using 1-[(1R)-2-hydroxy-1-methylethyl]-2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile (Example 329) and 6-fluoro-3-pyridinol: MS (ES) m/z 378 (M+1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07572820B2
Source datasetuspto-grants-2009_08
ORD IDord-011aed3661564c378a2602c8501e20f8
Source noteuspto-grants-2009_08