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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2102162Generated: October 29, 2026

3-Hydroxypyridine → 2-Methyl-1-[(1R)-1-methyl-2-(3-pyridinyloxy)ethyl]-4-(trifluoromethyl)-1H-indole-5-carbonitrile

https://huagongshe.com/reaction/2102162

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-HydroxypyridineHCID 7971—
Reactant1-[(1R)-2-Hydroxy-1-methylethyl]-2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrileHCID 67404820—
Product2-Methyl-1-[(1R)-1-methyl-2-(3-pyridinyloxy)ethyl]-4-(trifluoromethyl)-1H-indole-5-carbonitrileHCID 67405138—

Reaction Steps

Synthesized as described in Example 139C using 1-[(1R)-2-hydroxy-1-methylethyl]-2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile (Example 329) and 3-pyridinol: MS (ES) m/z 360 (M+1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07572820B2
Source datasetuspto-grants-2009_08
ORD IDord-1c8744cdcd384bd7a76ad7c8e2f824c1
Source noteuspto-grants-2009_08