HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Chloro-2-propanol → 1-(2-Hydroxypropyl)-2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Chloro-2-propanol | HCID 31370 | — |
| Reactant | 2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile | HCID 53309346 | — |
| Product | 1-(2-Hydroxypropyl)-2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile | HCID 67403809 | — |
Reaction Steps
Synthesized as described in Example 4 using 2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile (Example 120) and 1-chloro-2-propanol: 1H NMR (400 MHz, CDCl3) δ 7.53 (d, J=8.5 Hz, 1H), 7.48 (d, J=8.5 Hz, 1H), 6.59 (s, 1H), 4.20 (m, 1H), 4.12 (m, 2H), 2.52 (s, 3H), 1.33 (d, J=6.1 Hz, 3H); MS (ES) m/z 283 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07572820B2 |
| Source dataset | uspto-grants-2009_08 |
| ORD ID | ord-372dfe10826d420d9cedf2de2b351c4e |
| Source note | uspto-grants-2009_08 |