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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2102169Generated: October 30, 2026

1-(2-Hydroxypropyl)-2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile → 2-Methyl-1-[2-(2-pyridinyloxy)propyl]-4-(trifluoromethyl)-1H-indole-5-carbonitrile

https://huagongshe.com/reaction/2102169

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(2-Hydroxypropyl)-2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrileHCID 67403809—
ReactantHCID 178516071HCID 178516071—
Product2-Methyl-1-[2-(2-pyridinyloxy)propyl]-4-(trifluoromethyl)-1H-indole-5-carbonitrileHCID 67406632—

Reaction Steps

Synthesized as described in Example 139C using 1-(2-hydroxypropyl)-2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile (Example 335) and 2-pyridinol: MS (ES) m/z 360 (M+1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07572820B2
Source datasetuspto-grants-2009_08
ORD IDord-ead3ed94e4604223b53eacbc0cb3c67f
Source noteuspto-grants-2009_08