2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile → HCID 67405308, compound

HRID 2102170Notes

Reaction equation

HRID 2102170 reaction equation
[CH3:1][C:2]1[NH:3][C:4]2[C:9]([CH:10]=1)=[C:8]([C:11]([F:14])([F:13])[F:12])[C:7]([C:15]#[N:16])=[CH:6][CH:5]=2.[F:17][C:18]1[CH:25]=[C:24]([O:26][CH2:27][CH2:28]Br)[CH:23]=[CH:22][C:19]=1[C:20]#[N:21]>>[C:20]([C:19]1[CH:22]=[CH:23][C:24]([O:26][CH2:27][CH2:28][N:3]2[C:4]3[C:9](=[C:8]([C:11]([F:12])([F:14])[F:13])[C:7]([C:15]#[N:16])=[CH:6][CH:5]=3)[CH:10]=[C:2]2[CH3:1])=[CH:25][C:18]=1[F:17])#[N:21]

Participants

3

Reactant 2

HCID 533093462-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrileHCID 57920608HCID 57920608, compound

Product 1

HCID 67405308HCID 67405308, compound

Procedure

Synthesized as described in Example 4 using 2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile (Example 120) and 2-fluoro-4-[(2-bromoethyl)oxy]benzonitrile: MS (ES) m/z 388 (M+1).

Workup

  1. customSynthesized

Sources & evidence

ORD record
ord-7b9014074e9e4d4cab6efb19c9a881c7
Source dataset
uspto-grants-2009_08
Patent number
US07572820B2

Reaction notes

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