化工社化工社 化学情報印刷レポート · 研究参考用
1-Chloro-2-methylpropan-2-ol → 1-(2-Hydroxy-2-methylpropyl)-2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Chloro-2-methylpropan-2-ol | HCID 68409 | — |
| 反応物 | 2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile | HCID 53309346 | — |
| 生成物 | 1-(2-Hydroxy-2-methylpropyl)-2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile | HCID 67405604 | — |
反応手順
Synthesized as described in Example 4 using 2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile (Example 120) and 1-chloro-2-methyl-2-propanol: 1H NMR (400 MHz, CDCl3) δ 7.66 (d, J=8.5 Hz, 1H), 7.46 (d, J=8.5 Hz, 1H), 6.60 (s, 1H), 4.12 (s, 2H), 2.52 (s, 3H), 1.30 (s, 6H); MS (ES) m/z 297 (M+1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07572820B2 |
| 出典データセット | uspto-grants-2009_08 |
| ORD ID | ord-0f435fc62277422a936568c5e892a9c3 |
| 出典メモ | uspto-grants-2009_08 |