1,3-Dichloroacetone → 2-[3,5-Bis(trifluoromethyl)phenyl]-4-(chloromethyl)-1,3-oxazole

HRID 2102181Notes

Reaction equation

HRID 2102181 reaction equation
[F:1][C:2]([F:17])([F:16])[C:3]1[CH:4]=[C:5]([CH:9]=[C:10]([C:12]([F:15])([F:14])[F:13])[CH:11]=1)[C:6]([NH2:8])=[O:7].[Cl:18][CH2:19][C:20](=O)[CH2:21]Cl>>[F:1][C:2]([F:16])([F:17])[C:3]1[CH:4]=[C:5]([C:6]2[O:7][CH:21]=[C:20]([CH2:19][Cl:18])[N:8]=2)[CH:9]=[C:10]([C:12]([F:15])([F:13])[F:14])[CH:11]=1

Participants

3

Reactant 2

HCID 107931,3-DichloroacetoneHCID 5199273,5-Bis(trifluoromethyl)benzamide

Product 1

HCID 578004682-[3,5-Bis(trifluoromethyl)phenyl]-4-(chloromethyl)-1,3-oxazole

Procedure

Synthesized as described in Example 353A using 3,5-bis-(trifluoromethyl)benzamide and 1,3-dichloro-2-propanone: 1H NMR (400 MHz, CDCl3) δ 8.50 (s, 2H), 7.96 (s, 1H), 7.80 (s, 1H), 4.59 (s, 2H).

Workup

  1. customSynthesized

Sources & evidence

ORD record
ord-26879fc82187416a9985e19b7ce8893a
Source dataset
uspto-grants-2009_08
Patent number
US07572820B2

Reaction notes

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