Dimethylformamide → HCID 67334339, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 651 mg 5-(4-bromobenzyl)-1-cyclohexyl-3-[4-(trifluoromethoxy)phenyl]-1H-pyrazole from Step C Example 11, 95.7 mg zinc cyanide, 62.9 mg tetrakis(triphenylphosphine)palladium(0) in 2.5 mL DMF was heated under nitrogen in 80° C. oil bath for 24 hours. Evaporate most of DMF. The residue was purified on silica gel using 1 and 3% MeCN in methylene chloride to give the title compound as a yellow foam. 1H NMR (CDCl3, 600 MHz) δ 7.78˜7.81 (m, 2H), 7.63 (d, J=8.3 Hz, 2H), 7.33 (d, J=8.2 Hz, 2H), 7.215 (d, J=8.3 Hz, 2H), 6.25 (s, 1H), 4.09 (s, 2H), 3.83 (tt, J=3.9 & 11.7 Hz, 1H), 1.96˜2.03 (m, 2H), 1.85˜1.89 (m, 2H), 1.73˜1.77 (m, 2H), 1.68˜1.71 (m, 1H), 1.23˜1.33 (m, 3H). LC-MS: 2.63 min. (M+H=426).

Provenance & Evidence