Water → HCID 67335127, compound

Participants

Reaction Steps

To a mixture of 0.395 g 4-({1-cyclohexyl-3-[4-(trifluoromethoxy)phenyl]-1H-pyrazol-5-yl}methyl)benzonitrile from Step A above in 9 mL ethanol and 3 mL water was added 0.80 g potassium hydroxide pellets. The resulting solution was refluxed under nitrogen over night. Ethanol was removed under reduced pressure. The product was precipitated by adding 14 mL 1 N HCl to the residue. The title compound was collected by filtrated, washed with water several times, and dried to give a off-white solid. 1H NMR (CD3OD, 600 MHz) δ 7.97 (d, J=8.2 Hz, 2H), 7.81˜7.84 (m, 2H), 7.35 (d, J=8.2 Hz, 2H), 7.25 (d, J=8.2 Hz, 2H), 6.425 (s, 1H), 4.165 (s, 2H), 4.01 (tt, J=3.9 & 11.8 Hz, 1H), 1.86˜1.93 (m, 2H), 1.78˜1.83 (m, 2H), 1.64˜1.68 (m, 3H), 1.20˜1.35 (m, 3H). LC-MS: 2.49 min. (M+H=445.2).

Provenance & Evidence