Pyridine → HCID 67334934, compound

Participants

Reaction Steps

To a solution of the intermediate from Example 142 step F (156 mg, 0.35 mmol) in DCM (5 mL) was added pyridine (5 mL) and benzene sulfonyl chloride (68 μL, 0.53 mmol). After 4 hours the reaction was diluted with DCM and washed with 1N HCl (3×), dried over anhydrous Na2SO4 filtered and concentrated in vacuo. The residue was purified by flash chromatography using 1:5 ethyl acetate-hexanes to give the title compound a white foam. 1H NMR (CDCl3, 500 MHz): δ 7.99(d, J=8.3 Hz, 2H), 7.8(d, J=8.7 Hz, 2H), 7.7(d, J=1.9 Hz, 2H), 7.67(t, J=7.3 Hz, 1H), 7.58(t, J=8.0 Hz, 2H), 7.32(t, J=1.8 Hz, 1H), 7.1(d, J=8.2 Hz, 2H), 6.42(s, 1H), 5.55(s, 2H), 3.93(s, 3H), 3.90(d, J=12.2 Hz, 2H), 2.46(m, 1H), 2.31(m, 2H), 1.77(m, 3H).

Provenance & Evidence