Methyl iodide → HCID 69007762, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 6-bromo-7-fluoro-5-methyl-3H-imidazo[4,5-b]pyridine (1.00 equivalent) in DMF is added iodomethane (1.20 equivalents) and K2CO3 (1.50 equivalents) at room temperature. The resulting mixture is stirred at 75° C. for 1 hour. The reaction mixture is diluted with EtOAc and washed with water and brine. The organic layer is dried over MgSO4, filtered, and concentrated in vacuo to give the crude material that is purified by trituration or flash column chromatography to afford the desired product.

Provenance & Evidence