HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 69008047, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 18-Crown-6 | HCID 28557 | — |
| Reactant | Potassium Fluoride | HCID 522689 | — |
| Reactant | HCID 86599609 | HCID 86599609 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 69008047 | HCID 69008047 | — |
Reaction Steps
A mixture of 6,7-dichloro-5-methylpyrazolo[1,5-a]pyrimidine (1.00 equivalent), 18-crown-6 (5 mol %), and KF (3.00 equivalents) in MeCN is heated under reflux with stirring. After 17 hours, the reaction mixture is poured into water, extracted with EtOAc, dried (MgSO4), and concentrated. The product is purified by flash chromatography as necessary.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07576072B2 |
| Source dataset | uspto-grants-2009_08 |
| ORD ID | ord-02f8311940454d66886ddef4d513c532 |
| Source note | uspto-grants-2009_08 |