Acetone, oxime → HCID 69002585, compound

HRID 2102422Notes

Reaction equation

HRID 2102422 reaction equation
[CH3:1][O:2][C:3]([C:5]1[C:10]([NH:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[F:18])=[C:9]([F:19])[C:8](Cl)=[C:7]([C:21](=O)[CH3:22])[N:6]=1)=[O:4].[K].CC(=[N:28][NH2:29])C.CC(=NO)C>>[CH3:1][O:2][C:3]([C:5]1[C:10]([NH:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[F:18])=[C:9]([F:19])[C:8]2[C:7](=[C:21]([CH3:22])[NH:28][N:29]=2)[N:6]=1)=[O:4]

Participants

5

Reactant 4

HCID 67180Acetone, oximeHCID 789372-Propanone, hydrazoneHCID 5462222PotassiumHCID 66999313HCID 66999313, compound

Product 1

HCID 69002585HCID 69002585, compound

Procedure

The title compound is prepared from 6-acetyl-5-chloro-4-fluoro-3-(2-fluorophenylamino)-pyridine-2-carboxylic acid methyl ester (prepared in Example 8) and the potassium salt of acetone hydrazone in place of the potassium salt of acetone oxime by the method previously described in step H of Example 8.

Sources & evidence

ORD record
ord-f6f77a7f0936489fb85b8a9eb587c21a
Source dataset
uspto-grants-2009_08
Patent number
US07576072B2

Reaction notes

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