Acetone, oxime → HCID 178499042, compound

HRID 2102423Notes

Reaction equation

HRID 2102423 reaction equation
[CH3:1][O:2][C:3]([C:5]1[C:10]([NH:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[F:18])=[C:9]([F:19])[C:8](Cl)=[C:7]([C:21]#[N:22])[N:6]=1)=[O:4].[K].CC(=[N:27][NH2:28])C.CC(=NO)C>>[CH3:1][O:2][C:3]([C:5]1[C:10]([NH:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[F:18])=[C:9]([F:19])[C:8]2[C:7](=[C:21]([NH2:22])[NH:27][N:28]=2)[N:6]=1)=[O:4]

Participants

5

Reactant 4

HCID 67180Acetone, oximeHCID 789372-Propanone, hydrazoneHCID 5462222PotassiumHCID 69003486HCID 69003486, compound

Product 1

HCID 178499042HCID 178499042, compound

Procedure

The title compound is prepared from 5-chloro-6-cyano-4-fluoro-3-(2-fluorophenylamino)-pyridine-2-carboxylic acid methyl ester (prepared in Example 9) and the potassium salt of acetone hydrazone in place of the potassium salt of acetone oxime by the method previously described in step H of Example 8.

Sources & evidence

ORD record
ord-354cfea561514cd3986cf0a72197f858
Source dataset
uspto-grants-2009_08
Patent number
US07576072B2

Reaction notes

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