Ethyl propiolate → HCID 69055050, compound

Participants

Reaction Steps

A solution of the crude residue from example 131 and ethyl propiolate (2 mL) in xylenes (15 mL) was heated in a sealed tube at 150° C. for 4 hr. Concentration and chromatographic purification (25% ethyl acetate and hexanes) afforded 3-(5-ethoxycarbonyl-isothiazol-3-yl )-piperidine-1-carboxylic acid benzyl ester and 3-(4-ethoxycarbonyl-isothiazol-3-yl )-piperidine-1-carboxylic acid benzyl ester as a 1:1 mixture (1.24 g), MH+( LCMS) 375.1(m/z).

Provenance & Evidence