HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → N1-benzyl-N4-[1-(5-chloro-6-methoxy-2-naphthoyl)ethyl] piperazine dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Piperazine, 1-(phenylmethyl)-, hydrochloride (1:2) | HCID 12198046 | — |
| Reactant | 2-Bromo-1-(5-chloro-6-methoxynaphthalen-2-yl)propan-1-one | HCID 13699429 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | N1-benzyl-N4-[1-(5-chloro-6-methoxy-2-naphthoyl)ethyl] piperazine dihydrochloride | HCID 69055806 | 101.5% |
Reaction Steps
A mixture of N-benzyl piperazine dihydrochloride (1.5 g, 7.05 mmol), 2-bromo-1-(5-chloro-6-methoxynaphthalen-2-yl) propan-1-one (2.8 g, 8.5 mmol) and triethyl-amine (2.38 g, 23.5 mmol) in benzene (150 ml) was treated according to the general preparation 2 to obtain 2.14 g of N1-benzyl-N4-[1-(5-chloro-6-methoxy-2-naphthoyl)ethyl] piperazine dihydrochloride, yield 60%, mp 252-253° C.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07576086B2 |
| Source dataset | uspto-grants-2009_08 |
| ORD ID | ord-bf51c1241d4e4a97a06792b98dc794d7 |
| Source note | uspto-grants-2009_08 |