Cesium carbonate → HCID 68910325, compound

HRID 2102525Notes

Reaction equation

HRID 2102525 reaction equation
[S:1]1[CH2:6][C:5](=[O:7])[NH:4][C:3]2[CH:8]=[N:9][CH:10]=[CH:11][C:2]1=2.C([O-])([O-])=O.[Cs+].[Cs+].[Cl:18][CH2:19][CH2:20][CH2:21]I>>[Cl:18][CH2:19][CH2:20][CH2:21][N:4]1[C:5](=[O:7])[CH2:6][S:1][C:2]2[CH:11]=[CH:10][N:9]=[CH:8][C:3]1=2

Participants

4

Reactant 3

HCID 10796Cesium carbonateHCID 813631-Chloro-3-iodopropaneHCID 3730782H-Pyrido(4,3-b)(1,4)thiazin-3(4H)-one

Product 1

HCID 68910325HCID 68910325, compoundYield 110.1%

Procedure

4H-pyrido[4,3-b][1,4]thiazin-3-one (81MF939a) (0.087 g, 0.52 mmol), Cs2CO3 (0.256 g, 0.78 mmol) and 3-chloro-1-iodopropane (0.116 g, 0.57 mmol) were mixed according to GP5 giving the crude title compound (0.139 g). 1H NMR (CDCl3) δ 8.43 (s, 1H), 8.17 (d, J=5.2 Hz, 1H), 7.25 (d, J=5.2 Hz, 1H), 4.20-4.15 (m, 2H), 3.55 (t, J=6.2 Hz, 2H), 3.41 (s, 2H), 2.17-2.10 (m, 2H).

Sources & evidence

ORD record
ord-e5957ce00f29462fb8354c6fde05d0cc
Source dataset
uspto-grants-2009_08
Patent number
US07576078B2

Reaction notes

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