Potassium Iodide → HCID 11998661, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of rac-6-chloro-3-(4-isopropyl-phenyl)-1,3-dihydro-indol-2-one (0.11 g, 0.38 mmol) (from Example 53b supra), 3-chlorobenzyl bromide (0.093 g, 0.454 mmol) (Aldrich), potassium iodide (0.0762 g, 0.44 mmol) and potassium carbonate (0.114 g, 0.82 mmol) in acetone (3 mL) was heated at 70° C. for 3 hours. After cooling, mixture was partitioned between ethyl acetate and water. The aqueous layer was extracted with ethyl acetate three times. The combined organic layer was washed with water and brine, dried (Na2SO4), filtered and concentrated. Residue was purified by chromatography to give rac-6-chloro-3-(3-chloro-benzyl)-3-(4-isopropyl-phenyl)-1,3-dihydro-indol-2-one as brown solid. (Yield 0.09 g, 56.9%).

Provenance & Evidence