4-Chloro-6,7-dimethoxyquinazoline → HCID 11517828, compound

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Reaction Steps

N-[6-(6,7-Dimethoxyquinazolin-4-ylamino)benzoxazol-2-yl]benzamide was prepared by heating a mixture of N-(6-aminobenzoxazol-2-yl)benzamide (IM 1, 30 mg, 0.118 mmol) and 4-chloro-6,7-dimethoxyquinazoline (Fluorochem, 26.5 mg, 0.118 mmol) in ethanol (3 mL) to 80° C. for 2 h. The resulting precipitate was separated by filtration, washed with ethanol and dried (yellow solid, 38 mg, 85 μmol, 72%). LC/ESI-MS: m/z=442 [M+H]+; m/z=440 [M−H]−; Rt=2.43 min.

Provenance & Evidence