Methyl Acrylate → HCID 12469800, compound

Participants

Reaction Steps

To a solution of 1-aminopiperidine (100 g, 1.00 mol) in dry methanol at 0° C., methyl acrylate (99.0 ml, 1.10 mol) was added dropwise. The resulting mixture was stirred at room temperature overnight. After evaporation of the solvent, heptane was added to the residue, and the white solid (impurity) removed by filtration. The filtrate was concentrated to dryness to afford 80.0 g (43%) of the title compound as a yellow oil. Alternatively this reaction was performed at 50° C. using toluene as the solvent with a 0.7 molar excess of 1-aminopiperidine. Excess 1-aminopiperidine was removed from the residue by co-distillation with xylene, then toluene and then hexane.

Provenance & Evidence