2,4-Dioxo-[1,1']bipiperidinyl-3-carboxylic acid methyl ester → [1,1']Bipiperidinyl-2,4-dione

Participants

Reaction Steps

The ethyl ester product from step 3 was dissolved in 10% acetic acid (250 ml) and the solution boiled under reflux for one hour. The cooled reaction mixture was evaporated, and the residue purified by flash chromatography (CH2Cl2: acetone 9:1-1:1) to give 4.00 g (36%) of the title compound as a semi-solid.

Provenance & Evidence