Triethylamine → HCID 57804162, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of methyl 4-iodobenzoate (2.62 g, 10 mmol), Et3N (5 mL), acetonitrile (6 mL), Pd(OAc)2 (100 mg, 0.4 mmol) was added 2-trifluoromethylpropene (2.20 g, 20 mmol). The mixture was sealed and heated at 125° C. for 20 h. After cooling, the mixture was treated with sat. aq. Na2CO3 solution and extracted with EtOAc. The combined organic phases were washed with brine, dried (MgSO4), and evaporated. The residue was purified by column chromatography on silica gel to give methyl (E)-4-(3,3,3-trifluoro-2-methylprop-1-enyl)benzoate.

Provenance & Evidence