Lithium Hydroxide → HCID 57804148, compound

Participants

Reaction Steps

Methyl 4-(cyclopentylethynyl)-2-fluorobenzoate was dissolved in 10 mL of MeOH and 10 mL of 2N LiOH and the mixture was refluxed overnight. The MeOH was removed under vacuum and the basic layer was washed with EtOAC, acidified, and re-extracted with EtOAC. The organic layer was washed with brine, dried (Na2SO4), filtered and concentrated under vacuum to give the desired product (645 mg) as a beige solid. m/z=233 (M+1).

Provenance & Evidence