Hydrochloric Acid → Methyl 4-bromo-2-methylbenzoate

Participants

Reaction Steps

4-Bromo-2-methylbenzoic acid (5.0 g, 23 mmol) was suspended in methanol (30 mL). To the mixture was added a solution of HCl in diethylether (1.0M, 30 mL). The mixture was refluxed for 24 hours and concentrated to dryness. The residue was dissolved in EtOAc and washed with saturated sodium bicarbonate. The organic layer was washed with brine, dried (Na2SO4), filtered and concentrated under vacuum to give the desired compound (5.5 g) as a brown oil.

Provenance & Evidence