Ethanol → Ethyl 4-bromo-2-methylbenzoate

Participants

Reaction Steps

4-bromo-2-methylbenzoic acid (10 g, 46.5 mmol) was dissolved in 200 mL EtOH, 5 mL conc H2SO4 was added and the mixture was refluxed for 18 h. The reaction volume was reduced in vacuo to 50 mL, and neutralized to pH 7 with satd. aqueous NaHCO3 and extracted with EtOAc. The organic layer was dried (Na2SO4), filtered and the filtrate was concentrated to give the product (6.5 g) as an oil.

Provenance & Evidence