HuagongsheHuagongshe Chemistry Print Report · For research reference only
(E)-tert-butyl 2-fluoro-4-(3,3,3-trifluoroprop-1-enyl)benzoate → (E)-2-Fluoro-4-(3,3,3-trifluoroprop-1-enyl)benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (E)-tert-butyl 2-fluoro-4-(3,3,3-trifluoroprop-1-enyl)benzoate | HCID 68704410 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Trifluoroacetic acid | HCID 6422 | — |
| Product | (E)-2-Fluoro-4-(3,3,3-trifluoroprop-1-enyl)benzoic acid | HCID 57804152 | — |
Reaction Steps
A solution of (E)-tert-butyl 2-fluoro-4-(3,3,3-trifluoroprop-1-enyl)benzoate (500 mg, 0.002 mol) in CH2Cl2 (10 mL) and TFA (1.0 mL) was stirred at room temperature for 2 h. The solvent was removed under reduced pressure to give a white solid. LC-MS: 2.99 min, 233.2 (M−1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07576099B2 |
| Source dataset | uspto-grants-2009_08 |
| ORD ID | ord-56bb8415c9034898b5e4c462fd618d98 |
| Source note | uspto-grants-2009_08 |