Sodium Hydroxide → HCID 57804101, compound

Participants

Reaction Conditions

Reaction Steps

Methyl 2-chloro-5-fluoro-4-(3,3-dimethylbut-1-ynyl)benzoate (6.1 g, 22 mmol) was dissolved in MeOH (30 mL), sodium hydroxide (1.3 g, 33 mmol) (in 20 mL, water) was added and stirred at 60° C. overnight. Solvent was removed, residue was dissolved in water, neutralized by HCl till pH <2, extracted by EtOAc, washed by water, brine and dried over Na2SO4. Product was obtained as a beige solid (3.1 g, 52%).

Provenance & Evidence