(6-Nitro-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methanol → (6-Amino-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methanol

Participants

Reaction Steps

(6-Nitro-2,3-dihydro-benzo[1,4]dioxin-2-yl)-methanol (1.0 g, 4.7 mmol) was dissolved in methanol (30 mL) and palladium on activated carbon was added (0.10 g, 5% wt). The mixture was shaken on a Parr Shaker under H2(g) atmosphere (60 PSI) for 24 hours. The mixture was filtered through Celite® and evaporated to give 646 mg of material as a white solid (77%), which was used as such for the next step. m/z=182 (M+1). LC: 0.82 minutes.

Provenance & Evidence