HuagongsheHuagongshe Chemistry Print Report · For research reference only
Imidazole → HCID 69054406, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | Triisopropylsilyl chloride | HCID 139400 | — |
| Reactant | 6-hydroxy-5,7,8-trimethyl-chroman-2-one | HCID 297375 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 69054406 | HCID 69054406 | 58.3% |
Reaction Steps
A solution of 6-hydroxy-5,7,8-trimethyl-chroman-2-one (1.22 g), triisopropylsilyl chloride (1.71 g) and imidazole (806 mg, 11.84 mmol) in anhydrous DMF (2 mL) was stirred at room temperature for two days. The solution was diluted with ethyl acetate, washed with water and brine. Evaporation and chromatography (silica gel, hexane-ethyl acetate) gave 1.25 g of 5,7,8-trimethyl-6-triisopropylsilanyloxy-chroman-2-one.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07576094B2 |
| Source dataset | uspto-grants-2009_08 |
| ORD ID | ord-cd7a2b93766740c7b3252c25ac105b11 |
| Source note | uspto-grants-2009_08 |