反应详情

A mixture of 6-hydroxy-7,8-dimethyl-4H-spiro[chromene-3,1′-cyclopropan]-4-one (150 mg) and sodium borohydride (50 mg) in MeOH (15 mL) was stirred at room temperature for 2 h. After evaporation, the residue was applied to silica gel column eluting with 30-60% EtOAc in hexane to give 7,8-dimethyl-4H -spiro[chromene-3,1′-cyclopropane]-4,6-diol as an off-white solid (95 mg).

1. customAfter evaporation
2. washeluting with 30-60% EtOAc in hexane