O-Methylhydroxylamine hydrochloride → HCID 73047665, compound

Participants

Reaction Steps

To a solution of 6′-hydroxy-5′,7′,8′-trimethylspiro[cyclobutane-1,2′-thiochromen]-4′(3′H)-one prepared as described above (300 mg) in 2 mL of pyridine was added methoxyamine hydrochloride (192 mg, 2.3 mmol). The reaction mixture was allowed to stir overnight. The mixture was washed with water and extracted with ethyl acetate. After concentration in vacuo, the residue was purified by flash chromatography eluted with 20% ethyl acetate in hexane to give 150 mg of 6′-hydroxy-5′,7′,8′-trimethylspiro[cyclobutane-1,2′-thiochromen]-4′(3′H)-one O-methyloxime, as a white solid.

Provenance & Evidence