Dichloromethane → HCID 57803525, compound

Participants

Reaction Steps

To a solution of 7-chloro-7,8-dimethyl-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-6-ol (300 mg), prepared as described above, and dimethylaminoacetyl chloride hydrochloride (564 mg) in dichloromethane (8 mL) was added N-ethyldiiospropylamine (1.4 mL) dropwise at room temperature under nitrogen. The reaction mixture was stirred at room temperature for 16 hours. The solution was diluted with ethyl acetate and washed with water and brine, dried and evaporated. Chromatography (silica gel, hexane-ethyl acetate 5% to 25%) gave 276 mg of 7-chloro-5,8-dimethyl-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-6-yl (dimethylamino)acetate.

Provenance & Evidence