N-methylhydroxylamine hydrochloride → HCID 86605478, compound

Participants

Reaction Steps

A mixture of 5,7,8-trimethyl-4-oxo-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-6-yl acetate (110 mg), N-methylhydroxylamine hydrochloride (64 mg), and sodium acetate (63 mg) in methanol (5 mL) was refluxed for 5 h. The mixture was diluted with ethyl acetate, washed with water and brine, dried and evaporated to give 100 mg of 4-(methoxyimino)-5,7,8-trimethyl-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-6-yl acetate, which was used in the next step without further purification.

Provenance & Evidence